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Genetic Dry

Why I like it dry?

i loke Pinot Grigio, dry and all matter. there is a genetic pull, or is it just me?

And really not care and prefer Chardonnay CA pinots white Italian or French Bordeaux and CA Sauvignon Blancs and Pinot as well, eh? And with Chardonnay CA secondary malolactic fermentation, eh? With just a little silicone lubricant? I do not blame you!.

Rheumatoid arthritis is a genetic disease?

Rheumatoid arthritis (RA) is the most common inflammatory type of arthritis. It affects over 2 million Americans and remains the leading cause of disability and lost workdays. Home of RA is more common in women than in men, and typical of the disease is between 25 and 50 years of age. The symptoms of rheumatoid arthritis include swelling, loss of movement, stiffness and joint pain, more commonly, the fingers and wrists.

RA is to be feared and respected because it is a chronic systemic autoimmune disease that affects internal organs, and joints. While the cause of rheumatoid arthritis is not yet fully known, a recent study published in the New England Journal of Medicine carried out by researchers in the United States and Sweden links a genetic region to rheumatoid arthritis.

A new study indicates a genetic association new RA.

Researchers in the U.S. compared the genetic material of 908 RA patients from North American Rheumatoid Arthritis Consortium to genetic material of 1,282 individuals without RA. Swedish researchers compared DNA samples from 673 individuals without RA with genetic material from 676 individuals with RA were obtained from the epidemiological investigation of Swedish rheumatoid arthritis.

Both groups of researchers used the genome of the new approach wide association, which allows researchers to examine between 300,000 and 500,000 small discrepancies in the genetic material. The researchers examined genetic material in blood samples of all individuals who were part of the study.

The researchers found two genes on chromosome 9 responsible for inflammation associated with RA TRAF1 and C5. TRAF 1 codes for tumor necrosis factor, a specific target for many new biological medicines used to treat RA. Codes C5 complement, a protein that plays an important role in inflammation. Other predisposing genetic factors have been identified previously. These include HLA-DRB1 and PTPN22.

Elaine F. Remmers, Ph.D. in genetics and NAMS Genonics Branch Intramural Research Program and one of the authors of this study was identified in a press release, "TRAF1-C5 showed association not only in the shows we did with the North American Rheumatoid Arthritis Consortium, but also independently in the Swedish group. By combining our information, we have been able to make a much stronger case. The combined test was pretty impressive. "

Researchers are clear how these two genes are linked to RA and to which gene is causing the disease. Remmers said: "In fact, both candidate genes are very interesting. Both control inflammatory processes that really are relevant to the disease, so that could easily imagine any of them play a role – or both. "

The authors hope that future research may reveal more about how these genes are associated with RA. They also hope to learn more about the connection of disease genes, which are closer to the production of more effective treatment for the disease.

Remmers He continued: "We're hoping that we are in any of the variants of genes that will lead to new targets for therapy. Once we understand how the RA-associated variants work, we may be able interfere with the pathways the variants are influencing and either prevent the disease or prevent its progression. "

Author's note: Although the subject appears to be quite dry, this is really very exciting. Soon … , Or at least hope that soon we will be able to biopsy patients with RA when they come to identify genetic markers that have, and put these patients immediately on therapies that are expected to be put into complete remission or even heal.

About the Author

Nathan Wei, MD FACP FACR is a rheumatologist and Director of the Arthritis and Osteoporosis Center of Maryland. He is a Clinical Assistant Professor of Medicine at the University of Maryland School of Medicine. For more info:
Arthritis Treatment